MovDisordV3, Main, Exploration, bibRecord, 003707

The pallidosubthalamic projection: An anatomical substrate for nonmotor functions of the subthalamic nucleus in primates

Identifieur interne : 003707 ( Main/Exploration ); précédent : 003706; suivant : 003708

The pallidosubthalamic projection: An anatomical substrate for nonmotor functions of the subthalamic nucleus in primates

Auteurs : Carine Karachi [France] ; Jérôme Yelnik [France] ; Dominique Tandé [France] ; Léon Tremblay [France] ; Etienne C. Hirsch [France] ; Chantal François [France]

Source :

Movement Disorders [ 0885-3185 ] ; 2005-02.

RBID : ISTEX:D2C8B6C58EE0D9BD1100E68827C9AFC0CAAC2F2D

Descripteurs français

Pascal (Inist)
- Noyau sousthalamique, Primates, Projection, Système nerveux pathologie.

English descriptors

KwdEn :
- Animals, Biotin (analogs & derivatives), Biotin (metabolism), Calbindins, Dextrans (metabolism), Globus Pallidus (anatomy & histology), Globus Pallidus (metabolism), Immunohistochemistry (methods), Male, Nervous system diseases, Neural Pathways (anatomy & histology), Neural Pathways (metabolism), Primates, Projection, S100 Calcium Binding Protein G (metabolism), Subthalamic Nucleus (anatomy & histology), Subthalamic Nucleus (metabolism), Subthalamic nucleus, Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate (metabolism), axonal tracing, basal ganglia, globus pallidus, monkeys.
MESH :
- chemical , analogs & derivatives : Biotin.
- chemical , metabolism : Biotin, Dextrans, S100 Calcium Binding Protein G, Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate.
- anatomy & histology : Globus Pallidus, Neural Pathways, Subthalamic Nucleus.
- metabolism : Globus Pallidus, Neural Pathways, Subthalamic Nucleus.
- methods : Immunohistochemistry.
- Animals, Calbindins, Male, Primates.

Abstract

The subthalamic nucleus (STN) is the best target for correcting motor disability in parkinsonian patients with high‐frequency stimulation. However, STN stimulation has also been reported to modify cognitive, emotional, and motivational functions. The aim of this study was to analyze the topographic organization of the STN according to its inputs coming from the sensorimotor, associative, and limbic territories of the external globus pallidus (GPe) in monkeys, with special reference to the limbic projection. Axonal tracers were injected into the different functional territories of the GPe. Injection performed in the limbic GPe resulted in labeling of cell bodies in the dorsal nucleus accumbens and in a dense labeling of axons in the anterior and medioventral portion of the STN. In comparison, injections in the associative and sensorimotor GPe led to labeling in the central and dorsolateral parts of the STN, respectively. Individual pallidosubthalamic axons ramified into numerous varicose branches, which were restricted to a given territory in the STN. These data provide a functional cartography of this structure in primates and suggest that behavioral disorders observed in stimulated parkinsonian patients could result from a dysfunction of the limbic part of the STN. © 2004 Movement Disorder Society

Url:

https://api.istex.fr/document/D2C8B6C58EE0D9BD1100E68827C9AFC0CAAC2F2D/fulltext/pdf

DOI: 10.1002/mds.20302

Affiliations:

France
Paris

Le document en format XML

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<front><div type="abstract" xml:lang="en">The subthalamic nucleus (STN) is the best target for correcting motor disability in parkinsonian patients with high‐frequency stimulation. However, STN stimulation has also been reported to modify cognitive, emotional, and motivational functions. The aim of this study was to analyze the topographic organization of the STN according to its inputs coming from the sensorimotor, associative, and limbic territories of the external globus pallidus (GPe) in monkeys, with special reference to the limbic projection. Axonal tracers were injected into the different functional territories of the GPe. Injection performed in the limbic GPe resulted in labeling of cell bodies in the dorsal nucleus accumbens and in a dense labeling of axons in the anterior and medioventral portion of the STN. In comparison, injections in the associative and sensorimotor GPe led to labeling in the central and dorsolateral parts of the STN, respectively. Individual pallidosubthalamic axons ramified into numerous varicose branches, which were restricted to a given territory in the STN. These data provide a functional cartography of this structure in primates and suggest that behavioral disorders observed in stimulated parkinsonian patients could result from a dysfunction of the limbic part of the STN. © 2004 Movement Disorder Society</div>
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Movement Disorders (revue)

The pallidosubthalamic projection: An anatomical substrate for nonmotor functions of the subthalamic nucleus in primates

The pallidosubthalamic projection: An anatomical substrate for nonmotor functions of the subthalamic nucleus in primates

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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